diff --git a/engine/uwsgi.ini b/engine/uwsgi.ini
index 2103d899..66d4892a 100644
--- a/engine/uwsgi.ini
+++ b/engine/uwsgi.ini
@@ -95,6 +95,9 @@ die-on-term=true
 ; every request. It is not so slow, but with some kind of app/extensions that could be overkill.
 single-interpreter=true
 
+; Prevent uWSGI from consuming too much memory: https://github.com/grafana/oncall/issues/1521
+max-fd=1048576
+
 logger=stdio
 log-format=source=engine:uwsgi status=%(status) method=%(method) path=%(uri) latency=%(secs) google_trace_id=%(var.HTTP_X_CLOUD_TRACE_CONTEXT) protocol=%(proto) resp_size=%(size) req_body_size=%(cl)
 log-encoder=format ${strftime:%%Y-%%m-%%d %%H:%%M:%%S} ${msgnl}